This thesis examines Kant's and Nietzsche's treatments of the moral agent. It argues for three broad conclusions. Firstly, it argues that, although Nietzsche's explicit criticisms of Kant's conception of the moral agent can be understood only in the context of Nietzsche's broader moral philosophy, neither these criticisms nor their context are well understood by the prevailing literature. The thesis thus engages with existing scholarship on the nature of Nietzsche's moral philosophy and with the scanty literature on the relationship between Kant's (...) and Nietzsche's moral philosophies. Secondly, the thesis argues that Kant's conception of the moral agent is not undermined by the criticisms which Nietzsche explicitly levels at it, or, indeed, by others which are commonly made in Nietzsche's name. In doing so, the thesis combines original interpretations of Kant with elements of recent Kant scholarship. Finally, however, the thesis argues that neglected elements of Nietzsche's own moral philosophy provide for a more sophisticated, telling, and, indeed, original critical engagement with Kant's conception of the moral agent is not undermined by the criticisms which Nietzsche explicitly levels at it, or, indeed, by others which are commonly made in Nietzsche's name. In doing so, the thesis combines original interpretations of Kant with elements of recent Kant scholarship. Finally, however, the thesis argues that neglected elements of Nietzsche's own moral philosophy provide for a more sophisticated, telling, and, indeed, original critical engagement with Kant's conception of the moral agent. Thus the thesis defends an original interpretation of Nietzsche's moral philosophy and its critical relation to Kant's, and demonstrates the pertinence of a certain neglected critical approach to Kant's conception of the moral agent. On the basis of these conclusions, the thesis ultimately defends a conception of the moral agent which, although Kantian, owes something to both Kant and Nietzsche. (shrink)

In this essay, we aim to provide an overview of the political and philosophical issues pertaining to asexuality. The first section, “What Is Asexuality?,” offers an account of asexuality. The second section, “Asexuality as a Unique Sexual Orientation,” argues that asexuality should be understood as a unique sexual orientation. The third section, “Asexuality and Oppression,” discusses the various forms of oppression facing asexual persons today. The fourth section, “The Goods of Asexuality,” articulates some goods that asexuality brings to human lives, (...) and we do this with an eye toward conceiving of asexuality as something other than a mere deficit. (shrink)

George W. S. Bailey. prove that mental phenomena in general are not self- intimating in sense (3). Armstrong's argument is based on two claims: (a) Introspective awareness and its objects are distinct existences. (b) If introspective awareness ...

Cyclin-dependent kinase 5 has been implicated in Alzheimer's disease pathogenesis. Here, we demonstrate that overexpression of p25, an activator of cdk5, led to increased levels of BACE1 mRNA and protein in vitro and in vivo. A p25/cdk5 responsive region containing multiple sites for signal transducer and activator of transcription was identified in the BACE1 promoter. STAT3 interacts with the BACE1 promoter, and p25-overexpressing mice had elevated levels of pSTAT3 and BACE1, whereas cdk5-deficient mice had reduced levels. Furthermore, mice with a (...) targeted mutation in the STAT3 cdk5 responsive site had lower levels of BACE1. Increased BACE levels in p25 overexpressing mice correlated with enhanced amyloidogenic processing that could be reversed by a cdk5 inhibitor. These data demonstrate a pathway by which p25/cdk5 increases the amyloidogenic processing of APP through STAT3-mediated transcriptional control of BACE1 that could have implications for AD pathogenesis. (shrink)

Amyloid-beta peptide plaque in the brain is the primary diagnostic criterion of Alzheimer's disease . The physiological role of Abeta are poorly understood. We have previously determined an Abeta interacting domain in the promoters of AD-associated genes . This AbetaID interacts in a DNA sequence-specific manner with Abeta. We now demonstrate novel Abeta activity as a possible transcription factor. Herein, we detected Abeta-chromatin interaction in cell culture by ChIP assay. We observed that human neuroblastoma cells treated with FITC conjugated Abeta1-40 (...) localized Abeta to the nucleus in the presence of H2O2-mediated oxidative stress. Furthermore, primary rat fetal cerebrocortical cultures were transfected with APP and BACE1 promoter-luciferase fusions, and rat PC12 cultures were transfected with polymorphic APP promoter-CAT fusion clones. Transfected cells were treated with different Abeta peptides and/or H2O2. Abeta treatment of cell cultures produced a DNA sequence-specific response in cells transfected with polymorphic APP clones. Our results suggest the Abeta peptide may regulate its own production through feedback on its precursor protein and BACE1, leading to amyloidogenesis in AD. (shrink)

Originally published in 1913, this text was written in anticipation of the King's Speech for that year, which was due to include a Bill for the development of a National System of Education. The text puts forward the view that 'unless the Bill succeeds in making the most of the movement for reform springing from the schools themselves, it can but grant opportunities which will be incompletely utilised'. This book will be of value to anyone with an interest in the (...) history of education and educational reform. (shrink)

Extending previous research on the characteristics associated with adolescents’ general tendency to be a moral rebel, the present study examined the roles of moral identity and moral courage characteristics on 3 expressions of the tendency to stand up for one’s beliefs and values despite social pressure not to do so. Results revealed that general and situation-specific moral courage characteristics are important motivators of individuals’ caring, just, and brave expressions of the tendency to be a moral rebel, especially when they possess (...) a relatively strong moral identity. (shrink)

© 2017. The American Astronomical Society. All rights reserved.We present new observations of the low-mass companion to HD 984 taken with the Gemini Planet Imager as a part of the GPI Exoplanet Survey campaign. Images of HD 984 B were obtained in the J and H bands. Combined with archival epochs from 2012 and 2014, we fit the first orbit to the companion to find an 18 au orbit with a 68% confidence interval between 14 and 28 au, an eccentricity (...) of 0.18 with a 68% confidence interval between 0.05 and 0.47, and an inclination of 119°with a 68% confidence interval between 114°and 125°. To address the considerable spectral covariance in both spectra, we present a method of splitting the spectra into low and high frequencies to analyze the spectral structure at different spatial frequencies with the proper spectral noise correlation. Using the split spectra, we compare them to known spectral types using field brown dwarf and low-mass star spectra and find a best-fit match of a field gravity M6.5 ±1.5 spectral type with a corresponding temperature of K. Photometry of the companion yields a luminosity of log=2.88 ± 0.07 dex with DUSTY models. Mass estimates, again from DUSTY models, find an age-dependent mass of 34 ±1 to 95 ±4 M Jup. These results are consistent with previous measurements of the object. (shrink)

My project is to explain why the question ‘How does it feel to be a white problem?’ cannot be answered in the fluttering grammar of white talk. The whiteness of white talk lies not only in its having emerged from white mouths, but also in its evasiveness—in its attempt to suppress fear and anxiety, and its consequential [if unintended] reinscription and legitimation of racist oppression. I White talk is designed, indeed scripted, for the purposes of evading, rejecting, and remaining ignorant (...) about the injustices that flow from whiteness and its attendant privileges. I want to suggest a new point of entry—a way to flip the script, so to speak. -/- I begin with some observations about the basic advantages and disadvantages of using white talk as a route into the white problem. My account develops an expanded version of Alice MacIntyre’s definition of white talk that is attentive to the racialized bodily scripts that accompany white talk. I argue that white talk persists because it has an enduring and powerful moral, ontological, and epistemic pay off for white folks. I explore each payoff with an eye towards clarifying how white talk functions to maintain the illusion that we are invulnerable beings. Next, I pause to reply to the popular objection that this particular critique of white talk silences white people in conversations on race. If we cannot address the question ‘how does it feel to be a white problem’ in the fluttering grammar of white talk, then how shall we begin? In closing, I suggest that we might reduce fluttering by replacing white talk with a discourse of vulnerability, where vulnerability is defined not as weakness, but as a condition for potential. I offer some brief guidelines for how we might start this conversation. (shrink)

Seneca ‘Rhetor’ was last critically edited by H. J. Müller in 1887; the editions of H. Bornecque and W. A. Edward lack an apparatus criticus, though the latter's notes give some attention to textual points. Whoever next addresses himself to the task can take heart from Eduard Norden : ‘der Text ist schwer korrupt, für Konjekturalkritik noch viel zu tun.’ It may be added that he will do a service by jettisoning a large proportion of what Konjekturalkritik has already produced-too (...) much of this nature in Müller's text and apparatus, to say nothing of later contributions, is merely depressing. (shrink)

Transnational Cosmopolitanism is a text that aims to build upon Kant’s account of cosmopolitanism through the post-WWI writings and political life of W.E.B. Du Bois. Through the work of these two figures, Valdez constructs the notion of “transnational cosmopolitanism” to describe situations of global injustice and to imagine worlds otherwise. By demonstrating the limits of Kantian cosmopolitanism through an anti-colonial reading of “Perpetual Peace,” Transnational Cosmopolitanism illustrates how these limits still emerge within neo-Kantian frameworks and writing. In order to overcome (...) these limitations, Valdez artfully utilizes Du Bois’ political writings and his radical coalitional politics to argue that Du Bois’ writings and actions should inform our theorization and normative insights. This text provides a unique and robust contribution to the literature of cosmopolitanism that questions the current use of Kant’s canonical approach and enlists overlooked readings and resources to compose a transnational cosmopolitanism. (shrink)

: The achievements of Anna Julia Cooper are extraordinary given her life circumstances. Driven by a desire Cooper called "a thumping within," she became a prominent educator, earned her Ph.D., and influenced the thought of W.E.B. DuBois and others. Cooper fought for her educational philosophy, but despite her contributions, her apparent elitism has shaped contemporary assessments of her work. I argue that her views must be considered in social and historical context.